Cambridge Healthtech Institute’s 2nd Annual

Targeting Transcription Factors

Tools, Strategies & Small Molecule Modulators to Pursue Undruggable Targets

April 1, 2024

Transcription factors (TF) are proteins with DNA-binding domains that are involved in transcribing DNA into RNA. Transcription factors have been targeted in different ways—by modulating their binding, interactions, activity, or expression levels, to generate the desired biological outcomes. However, their lack of defined structure and binding pockets have made them inherently “difficult-to-target.” This symposium on Targeting Transcription Factors brings together scientists who are working on innovative chemistries and technologies to modulate these promising drug targets for therapeutic intervention.

Coverage will likely include:

Progress in targeting transcription factors like Myc, p53, STAT, TEAD, HIF, Nrf2, IKZF, and more
Utilizing innovative biophysical and structural technologies to understand inherent TF disorder
New screening platforms and models for identifying transcription factor modulators
Chemical biology and protein degradation strategies for targeting transcription factors
Development of small molecule inhibitors and activators of transcription factor-driven pathways
Emerging allosteric modulators and degraders of transcription factors

The deadline for priority consideration is September 15, 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

We hope you can join us for the three concurrent afternoon symposia during the first day of our 19th Annual Drug Discovery Chemistry event. Add on to your registration and attend the main event starting the next day. With two sets of five parallel conferences, you can also move back and forth to create your own agenda.

Opportunities for Participation: