Cambridge Healthtech Institute’s 16th Annual

Protein-Protein Interactions

Targeting Molecular Complexes for New Small Molecule Drug Discovery

APRIL 12 - 13, 2023

The Protein-Protein Interactions conference covers medicinal, biophysical, and structural chemists’ progress in discovering or designing compounds to modulate ‘difficult-to-drug' disease targets. Usually the PPI target is an intracellular protein that is part of a complex with other proteins or nucleic acids. Many diseases are caused by complexes of proteins that come together or fall apart when they’re not supposed to. Typically PPIs lack structural grooves for small molecule drug candidates to fit within; usually the protein target isn’t an enzyme so there isn’t even a catalytic pocket for a small molecule to block. Join colleagues to learn about and discuss recent and more frequent success in addressing PPI targets. Hear about progress-enabling approaches such as fragment-based drug discovery (FBDD), covalent approaches, and deploying bigger yet cell-penetrable molecules such as macrocyclic peptides.