Protein Degraders & Molecular Glues – Part 1 Icon

Cambridge Healthtech Institute’s 7th Annual

Degraders & Molecular Glues – Part 1

Designing and Optimizing PROTACs and Glues for Pursuing Undruggable Targets

April 2-3, 2024


Protein degraders and molecular glues are being developed to disrupt protein-protein interactions and to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. Hetero-bifunctional degraders like proteolysis-targeting chimeras (PROTACs) and monovalent degraders like molecular glues are being used to seek out previously “undruggable” targets for therapeutic intervention. This is giving rise to novel covalent chemistries, better understanding of degradation biology, and innovative techniques for inducing proximity. However, challenges do exist in terms of specificity, stability, biodistribution, and penetration of these degrader molecules. This two-part conference on Degraders & Molecular Glues brings together experts in the field to discuss important issues underlying the use of targeted protein degradation and induced proximity as a new therapeutic approach.


Coverage will likely include:


  • Rational design, characterization, and optimization of protein degraders and glues
  • Using covalent chemistries to induce proximity and degradation
  • Optimization of DMPK-PD properties, solubility, formulation, tissue penetration, and more
  • Update on emerging PROTACs, molecular glues, and new degrader modalities
  • Safety and toxicity concerns surrounding degraders and glues    


The deadline for priority consideration is September 15, 2023.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 19th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.


Opportunities for Participation:


For more details on the conference, please contact:

Tanuja Koppal, PhD

Senior Conference Director

Cambridge Healthtech Institute



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431