Cambridge Healthtech Institute’s 7th Annual

Degraders & Molecular Glues – Part 1

Designing and Optimizing PROTACs and Glues for Pursuing Undruggable Targets

APRIL 2 - 3, 2024

Protein degraders and molecular glues are being developed to disrupt protein-protein interactions and to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. Hetero-bifunctional degraders like proteolysis-targeting chimeras (PROTACs) and monovalent degraders like molecular glues are being used to seek out previously “undruggable” targets for therapeutic intervention. This is giving rise to novel covalent chemistries, better understanding of degradation biology, and innovative techniques for inducing proximity. However, challenges do exist in terms of specificity, stability, biodistribution, and penetration of these degrader molecules. This two-part conference on Degraders & Molecular Glues brings together experts in the field to discuss important issues underlying the use of targeted protein degradation and induced proximity as a new therapeutic approach.