Cambridge Healthtech Institute’s 6th Annual
Protein Degraders & Molecular Glues - Part 2
Emerging Degrader Modalities and Screening Strategies
APRIL 12 - 13, 2023
The ubiquitin-proteasome, lysosome, and autophagy systems are all well-controlled, selective pathways for intracellular protein degradation and turnover, and act as key regulators in cancer, CNS, and other diseases. However, a new generation of inhibitors
and activators are now being developed to disrupt protein-protein interactions and hijack these systems for targeted protein degradation or stabilization. Using this strategy, Proteolysis-targeting chimeras (PROTACs), molecular glues, and other small
molecule modalities are being used to seek out previously “undruggable” targets for therapeutic intervention. However, challenges do exist in terms of specificity, stability, biodistribution, and penetration of these degrader molecules.
This two-part conference on Protein Degraders & Molecular Glues brings together experts in the field to discuss important issues underlying the use of targeted protein degradation as a new therapeutic approach.