Degraders & Molecular Glues – Part 2

Bi-functional degraders like Proteolysis-targeting chimeras (PROTACs), monovalent degraders like molecular glues and other emerging degrader modalities are being used to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. They are seeking out previously “undruggable” targets for therapeutic intervention by exploring novel chemistries and chemical spaces and using innovative assays and screening tools to better understand and predict complex cellular interactions. This two-part conference on Degraders & Molecular Glues brings together experts in the field to discuss opportunities and challenges involved in pursuing targeted degradation and induced proximity as viable therapeutic strategies.