Degraders & Molecular Glues: Beyond Oncology Icon

Cambridge Healthtech Institute’s Inaugural

Degraders & Molecular Glues: Beyond Oncology

Designing and Optimizing PROTACs and Glue Modalities for Diverse Therapeutic Indications

April 14, 2025

 

Protein degraders and molecular glues are being developed to disrupt protein-protein interactions and to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. While most of the hetero-bifunctional degraders like proteolysis-targeting chimeras (PROTACs) and monovalent degraders like molecular glues are being used to target cancer, there are some headwinds driving non-oncology indications as well. This inaugural symposium that focuses on applications of Degraders & Molecular Glues: Beyond Oncology will be followed by a two-part conference on Degraders & Molecular Glues which emphasizes the growing use of targeted protein degradation and induced proximity as a new therapeutic approach.

 

Coverage will likely include:

 

  • Emerging PROTACs, molecular glues, and new degrader modalities for non-oncology indications
  • Update on degraders in the clinic for inflammation, CNS, and more
  • Finding new ligases and mechanisms for targeted degradation in diverse therapeutic areas
  • Pursuing extracellular and hard-to-drug intracellular targets for degradation
  • Exploring degradation of RNA and lipids as drug targets for intervention

 

The deadline for submission is October 7, 2024.

 

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

 

Opportunities for Participation:

 


For more details on the conference, please contact:

Tanuja Koppal, PhD

Senior Conference Director

Cambridge Healthtech Institute

Email: tkoppal@healthtech.com

 

For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431

Email: kskahan@healthtech.com