Fragment-Based Drug Discovery Icon

Cambridge Healthtech Institute’s 18th Annual

Fragment-Based Drug Discovery

Small Molecule Hits to Leads to Drug Candidates via FBDD

April 11-12, 2023


Join us for Cambridge Healthtech Institute’s 18th Annual Fragment-Based Drug Discovery conference, the oldest ‘fragment-focused’ conference in the drug discovery industry. Not only is fragment-based lead discovery now a part of many hit-finding screening campaigns, in some cases fragment-based drug discovery (FBDD) enabled progress against difficult targets such as KRAS. Hear examples of integrating fragment-based screens with other lead generation approaches. Learn fragment-to-drug stories from medicinal chemists who initiated such projects. Discuss traditional challenges of growing fragments into leads and strategize about the latest: fragment-enabled targeted protein degradation (TPD) approaches.


Coverage will likely include:


  • Advances in biophysical tools for fragment screening (e.g. NMR, affinity mass spectrometry)
  • Covalent fragments (especially for TPD applications)
  • Synthetic chemistry for enabling fragment-to-lead steps
  • Serial crystallography to grow fragment hits
  • Fragment-based ligand design (FBLD) in the absence of crystal structures
  • Integrating hits from different screening campaigns (such as DNA-encoded libraries or high-throughput screening)
  • Case studies of fragments for difficult targets (protein-protein or nucleic acid interactions, membrane proteins)
  • Examples of fragment-assisted drug development (e.g. fragment-based scaffold hopping)
  • Fragment-to-market success stories
  • New approaches in fragment library design (e.g. encoded libraries for fragments)


The deadline for priority consideration is September 23, 2022.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 18th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.


Opportunities for Participation:



For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director and Lead Content Director for Drug Discovery Chemistry

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431