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Cambridge Healthtech Institute’s 17th Annual

Fragment-Based Drug Discovery

From Fragment Hit to Lead to Optimization to Small Molecule Drug Candidate

April 19-20, 2022


Fragment-based drug discovery (FBDD) continues to be a fairly fruitful approach for many biophysical and medicinal chemists when initiating screening campaigns to arrive at new small molecule drug leads. Fragment libraries as opposed to typical small molecule libraries are proving especially useful against targets that are often difficult for small molecules to bind, such as flatter and larger targets without good pockets like many protein-protein interaction (PPI) targets. Often the fragment hits highlight new chemical space to be explored for growing the fragment into a drug lead. However it’s usually not as simple as it sounds. Join us at Cambridge Healthtech Institute's 17th Annual Fragment-Based Drug Discovery conference to share and discuss strategies and challenges with fellow FBDD practitioners in biopharma and academics. 


Coverage will likely include:


  • Examples of ‘fragment-assisted’ drug discovery; integrating hits from different types of screening campaigns such as DEL and HTS
  • Success stories of FBDD for difficult targets
  • Applications of covalent fragments, especially for targeted protein degradation
  • Fragment library design questions: What is the optimal size and/or diversity of a fragment library? How important is fraction sp3? 19F library considerations; pros and cons of target-focused libraries
  • New synthetic chemistry to help evolve fragment hits 
  • Advances in biophysical methods for determining fragment hits from primary or secondary screens – is NMR still king? 
  • Serial crystallography to grow fragment hits 
  • Fragment-based ligand design (FBLD) in the absence of crystal structures
  • CryoEM in FBDD


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is October 1, 2021.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the 4 concurrent day-and-a-half conferences during the first half of our 17th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda, whether you join in person or virtually.


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Aimee Croke
Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5458