DNA-Encoded Libraries

DNA-Encoded Libraries (DELs) are increasingly being used in the drug discovery industry to identify novel chemical matter with therapeutic potential. This lead generation approach uses combinatorial biology to synthesize chemical building blocks tagged with DNA, allowing protein targets to be screened against greater numbers of molecules more efficiently than traditional methods. While DEL technology expands the pool of potential hits, it also intensifies the challenge of selecting the most viable drug candidates. The field is also pushing boundaries by applying DEL to more difficult targets, such as membrane proteins, and exploring advanced applications like discovering molecular glues and covalent binders. At Cambridge Healthtech Institute’s 8th Annual DNA-Encoded Libraries (DEL) conference, join experienced discovery chemists and DEL practitioners to hear about innovations, exchange best practices, and discuss practical challenges.