Cambridge Healthtech Institute’s 6th Annual

Encoded Libraries for Drug Discovery

DNA-Encoded Libraries (DELs) for Expanding Chemical Space

April 2-3, 2024

DNA-Encoded Libraries (DELs) are increasingly being used in the drug discovery industry to find new chemical matter with drug potential. This newest lead generation approach uses combinatorial biology to synthesize chemical building blocks with DNA tags so one's protein (usually) target-of-interest can be screened against a greater number of molecules and at a more rapid pace. However, with more hits comes the challenge of selecting the ones that can become the most viable drug candidates. Applying DEL to a wider range of targets is also at the forefront of advances in the field. At Cambridge Healthtech Institute's Encoded Libraries for Drug Discovery conference, join medicinal chemistry colleagues to hear from innovators and discuss best practices, successes, and remaining challenges with fellow practitioners.

Coverage will likely include:

Expanding DEL applications to targets such as GPCRs and RNA
Using AI to streamline hit selection or expand chemical space
DEL for targeted protein degradation (TPD) strategies
Constructing fragment libraries using DEL approaches
Expanding DNA-compatible reactions for chemical building blocks
Case studies of DEL-origin compounds progressing in drug development
New strategies for confirming DEL hits
Applying DEL for macrocyclic peptides and 'larger' small molecules

The deadline for priority consideration is September 15, 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 19th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.

Opportunities for Participation: