Cambridge Healthtech Institute’s 7th Annual

DNA-Encoded Libraries

Expanding Chemical Space for Small Molecule-Based Drug Discovery

April 16-17, 2025

At Cambridge Healthtech Institute’s 7th Annual DNA-Encoded Libraries (DEL) conference, learn why DEL approaches are claiming space as an ‘entry-level’ drug-lead generation strategy within the pharmaceutical industry, often as a complement to high-throughput screening and sometimes even as a contender. The conference also explores newer applications of DEL such as for discovering molecular glues and covalent binders, as well using DEL for DEL-difficult targets such as membrane proteins. Join experienced discovery chemists and biologists to share innovative methodologies and real-world DEL applications for discovering novel small molecules, macrocyclic peptides, and more—all in the pursuit of expanding chemical space for new drug development.

Coverage will likely include:

Case studies on DEL-delivered hits and lead optimization
DEL-origin stories for drug candidates
Combining DEL results with leads from other hit-finding campaigns
Biophysical tools for DEL screening (e.g., afffinity-selection mass spectrometry (ASMS)
DEL for difficult targets such as GPCRs (G protein-coupled receptors)
Newer DEL applications: targeted-protein degradation, fragment-based drug discovery, and covalent-based drug discovery
Impact of machine learning/AI on DEL
DEL for macrocyclic peptides

The deadline for priority consideration is September 27, 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: