MONDAY, AUGUST 24 | 10:00 AM - 1:00 PM

Immunology is a field that appears to have a high barrier to entry.  There are with numerous cell types, each with multiple functions; and innumerable molecules with non-informative names like CD3, TNF-alpha and IL-4.  Non-immunologists often have difficulty understanding the immune system as a whole, and its various functions in human health and disease.  This course will simplify immunology by focusing on the big picture, and thereby addressing the gaps in knowledge that most chemists have. It’s not a comprehensive course – but hopefully better – a useful course. The focus will range from basic background biology and terminology that immunologists take for granted, and then jump to the biological underpinnings of the areas and targets a lot of medicinal chemists are developing compounds against.

Topics to be Covered:

  • Language of Immunology
  • Organization of the immune system
    • Inflammation and innate immunity
    • Functions of T cells and B cells
  • Molecular Basis of Pathogenic Immune Responses
    • Biologic defects of Autoimmune Diseases
    • Associated drug targets
  • Principles of Immuno-oncology
    • Biology of current therapies like checkpoint blockade
    • Newer drug targets – what is on the horizon?


Bauler_TimothyTimothy Bauler, PhD, Assistant Professor, Biomedical Sciences, Western Michigan University School of Medicine

Tim Bauler is a full-time medical educator who teaches immunology and infectious disease in an integrated curriculum combining basic science with clinical applications. Tim received a PhD in Microbiology and Immunology from the University of Michigan after studying the role of protein tyrosine phosphatases in regulating proximal T cell signal transduction. His postdoctoral fellowship at Rocky Mountain Laboratories, NIAID, NIH, focused on the innate immune response to intracellular bacterial pathogens, including Salmonella Typhimurium and highly virulent Francisella tularensis which must be studied under Biosafety Level 3 containment.

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