Tuesday, April 9
5:10 PLENARY KEYNOTE: Chemical Biology of Proteostasis
Jack Taunton, PhD, Professor, Department of Cellular and Molecular Pharmacology, University of California San Francisco
We have recently discovered several macrocyclic compounds that potently and selectively modulate protein homeostasis. I will discuss our recent efforts to unravel their molecular mechanisms.
Thursday, April 11
8:55 PLENARY KEYNOTE:
New Ways of Targeting K-Ras
Frank McCormick, PhD, Professor, HDF Comprehensive Cancer Center, University of California San Francisco
Efforts to find drugs that bind K‐Ras directly have increased recently, enabled by NMR‐based fragment screening, di-sulfide tethering, in silico drug design and biophysical methods such as Second Harmonic Generation (SHG). We will report progress on attacking
two sites in the K‐Ras protein; cysteine‐185 (the site of prenylation), and histidine‐95, a residue unique to K‐Ras, to develop covalent K‐Ras inhibitors, as well as compounds identified by SHG and other methods.