Chemical Space bRo5: Macrocyclics, PROTACs and More Icon

Cambridge Healthtech Institute’s Inaugural

Chemical Space bRo5: Macrocyclics, PROTACs & More

Next-Generation Oral-Based Drug Modalities beyond the Rule-of-Five

April 20-21, 2022


Cambridge Healthtech Institute’s Inaugural Chemical Space bRo5 conference focuses on newer, larger molecules such as synthetic macrocyclics, PROTACs, molecular glues and multi-specific drugs; all are of high interest for disrupting intracellular protein-protein interactions (PPIs) or accomplishing targeted protein degradation (TPD). Larger compounds deviate from the five properties common to most successful small molecule drugs as delineated by Christopher Lipinski over two decades ago. Share the latest with medicinal, computational and biophysical chemistry colleagues around increasing permeability, oral bioavailability and addressing lead optimization challenges for some of the newest drug modalities in biomedical research.


Coverage will likely include:


  • Common ‘drug-like’ properties of next-gen chemical matter with orally biovailable potential   
  • Synthetic chemistry strategies for macrocyclics and constrained peptides  
  • Lead optimization challenges for PROTACs and molecular glues
  • What makes a good bRo5 target? 
  • Transporters for intracellular delivery of large molecules 
  • Case studies of next-gen chemical matter (macrocyclics, protein degraders, multispecific drugs)


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is October 1, 2021.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the 3 concurrent day-and-a-half conferences during the second half of our 17th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda, whether you join in person or virtually.


For more details on the conference, please contact:

Tanuja Koppal, PhD or Anjani Shah, PhD

Senior Conference Directors

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252

Email: or


For partnering and sponsorship information, please contact:

Aimee Croke
Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5458