Cambridge Healthtech Institute’s 8th Annual

Degraders & Molecular Glues – Part 1

Design, Delivery & Optimization of PROTACs and Glue Modalities

April 15 - 16, 2025 ALL TIMES PDT

Hetero-bifunctional degraders like Proteolysis-Targeting Chimeras (PROTACs) and monovalent degraders like molecular glues are being developed to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. They are seeking out previously “undruggable” targets for therapeutic intervention by exploring novel chemistries and using innovative approaches to better understand the complex cellular biology underlying degradation and proximity. This two-part conference on Degraders & Molecular Glues brings together experts in the field to discuss the importance and applications of targeted degradation and induced proximity as a new therapeutic approach.

6:00 pm MONDAY, APRIL 14: Dinner Short Course*

SC1: Protein Degraders: A Beyond Rule of Five Space and in vitro ADME Perspective

*Premium Pricing or separate registration required. See Short Courses page for details.