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Cambridge Healthtech Institute’s 15th Annual

Protein-Protein Interactions

Targeting Intracellular Molecular Complexes for New Drug Discovery

April 20-21, 2022


Many diseases are caused by protein-protein interactions (PPIs): complexes of proteins that come together or fall apart when they’re not supposed to. However traditional small molecule, oral-based drugs are designed to inhibit single protein enzymatic targets in the cell which are relevant only to a small subset of diseases. One reason PPIs are more difficult to therapeutically target is because their structure is larger, flatter and harder for small molecules to specifically bind to and block. At Cambridge Healthtech Institute’s Protein-Protein Interactions conference, hear how medicinal, biophysical, structural and computational chemists are applying biophysical advances and newer approaches such as covalent modification and fragment-based drug design (FBDD) to discover, design and optimize new chemical matter that can enter cells and modulate this harder set of disease-relevant targets.  


Coverage will likely include:


  • Biophysical screens and other new technologies for identifying PPI modulators
  • Advances in structure-based drug design, including cryoEM for addressing PPI targets 
  • PPI-targeted covalent inhibitors 
  • Destroy what you can’t inhibit: PPI targets best suited for targeted protein destruction (TPD)
  • Progress on modulating ‘hot’ PPI targets (KRAS, BCL complexes, antiviral complexes) 
  • Targeting PPIs in neurodegenerative diseases (Alzheimer’s and Parkinson’s disease targets)
  • Making ‘larger’ small molecules to modulate PPIs


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is October 1, 2021.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the 3 concurrent day-and-a-half conferences during the second half of our 17th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda, whether you join in person or virtually.


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Aimee Croke
Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5458