Protein-Protein Interactions

Cambridge Healthtech Institute’s 14th Annual

Protein-Protein Interactions

Expanding Druggable Space by Targeting Intracellular PPIs

May 19-20, 2021

Cambridge Healthtech Institute's 14th Annual Protein-Protein Interactions conference focuses on small drug-like molecules with potential to disrupt or stabilize disease-relevant, intracellular, protein-protein interactions (PPIs). Many important disease targets are intracellular PPIs, such as those for cancer, Alzheimer’s, Parkinson’s and viral infections. Once considered 'undruggable,' PPIs are complexes of proteins whose large, flat surfaces are typically harder to inhibit by small molecules. However, small molecules continue to be a focus of intracellular PPI-targeted therapeutics because of their cell permeability and potential for oral bioavailability. Small molecule progress against PPIs has been spurred by recent advances in biophysical approaches, applications of fragment-based ligand design and better computational models. Join colleagues to stay abreast of the PPI-targeted compounds progressing in the clinic and other advances and challenges in the field.


Coverage will likely include:


  • PPI-targeted compounds against: KRAS, p53, MCL, MDM, beta-catenin and more
  • Targeting PPI complexes such as viral targets, neuro-degeneration targets, transcriptional regulatory complexes, degradation or apoptosis cascades
  • Covalent inhibitor design
  • Biophysical tools for PPI inhibitor screening: NMR, SPR, MS, TSA, ITC, MST
  • Structural insights from Cryo-EM and other tools for rational design of PPI-targeted compounds
  • Designing allosteric inhibitors, especially for kinases  


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is December 18, 2020.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the three concurrent day-and-a-half conferences during the second half of our 16th Annual Drug Discovery Chemistry event. Joining this virtual community in real-time allows you to ask questions of the speakers and engage with colleagues. Plus, you can return later to view the concurrent presentations and Q&A panels that you missed, via On-Demand access. 


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-628