Cambridge Healthtech Institute’s 19th Annual

Fragment-Based Drug Discovery

Fragment-Based Lead Design (FBLD) for New Small Molecule Therapeutic Candidates

April 2-3, 2024

Fragment-based drug discovery approaches have proven fruitful for finding new drug candidates, especially against non-enzymatic intracellular targets such as protein-protein interactions (PPIs), including molecular glues, that lack a typical pocket for an inhibitor to bind within. Cambridge Healthtech Institute's Fragment-Based Drug Discovery conference covers the latest refinements to fragment libraries, innovations in biophysical approaches for screening fragment hits, and case studies of growing a fragment hit into a drug lead and beyond. The challenges of integrating information from other lead generation approaches like DNA-encoded libraries, and other timely topics, will also be on the agenda and/or part of discussions with fellow medicinal chemists.

Coverage will likely include:

Innovations in biophysical tools for screening fragment libraries (e.g. 19F NMR, affinity-selective mass spec)
Covalent fragments, especially for targeted protein degradation (TPD)
Growing fragment hits in the absence of information from x-ray crystallography
DNA-Encoded Libraries (DEL) and other new approaches for fragment library design
Case studies on FBDD enabling progress against difficult targets
Fragment 'assisted' drug design: lead generation based on various hit-finding campaigns
Fragment 'success' stories (examples of fragment-origin drug candidates or recent launches)

The deadline for priority consideration is September 15, 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 19th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.

Opportunities for Participation: