Fragment-Based Drug Discovery

Cambridge Healthtech Institute’s 16th Annual

Fragment-Based Drug Discovery

From Fragments of Organic Compounds to Drug Leads to Medical Pills

May 18-19, 2021

Fragment-based drug discovery (FBDD), an increasingly successful approach for finding initial 'drug-like' hits upon which to chemically build small molecule drug leads, is particularly compelling for difficult drug targets such as protein-protein interactions (PPIs) that often lack good small molecule binding sites. Cambridge Healthtech Institute's 16th Annual Fragment-Based Drug Discovery conference convenes FBDD practitioners to discuss advances in the field such as building upon covalent fragments for drug leads, pros and cons of various fragment libraries and applying orthogonal biophysical methods to screen for and prosecute hits. We will also delve into 'fragment-assisted drug discovery' – how best to combine hits from fragment screens with other drug lead-generation approaches such high-throughput screening campaigns or encoded libraries.


Coverage will likely include:


  • Examples of FBDD drug candidates progressing in trials 
  • Case studies on FADD (fragment-assisted drug development)
  • Success stories: from fragment to medicine
  • Covalent fragments for new drug discovery
  • Serial crystallography to grow fragment hits
  • Fragment-based ligand design in the absence of crystallography structural information
  • Advances in NMR and other biophysical tools for FBLD


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is December 18, 2020.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the three concurrent day-and-a-half conferences during the first half of our 16th Annual Drug Discovery Chemistry event. Joining this virtual community in real-time allows you to ask questions of the speakers and engage with colleagues. Plus, you can return later to view the concurrent presentations and Q&A panels that you missed, via On-Demand access. 


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-628