Encoded Libraries for Small Molecule Discovery Icon

Cambridge Healthtech Institute’s 4th Annual

Encoded Libraries for Small Molecule Discovery

Expanding Chemical Space for New Drug Leads

April 19-20, 2022


DNA-encoded libraries (DEL) are increasingly becoming a strategy for small molecule drug-lead generation campaigns. How to quickly validate the many hits and/or incorporate them with results from other types such as high-throughput screening (HTS) campaigns, is still a challenge. Join Cambridge Healthtech institute’s 4th Annual Encoded Libraries for Small Molecule Discovery conference to learn from and share with colleagues approaches or examples that have proved useful. Questions such as medicinal chemistry lead optimization challenges, when to use DEL versus other screening approaches like fragment-based drug discovery (FBDD) or HTS, and how to increase the chemical diversity in DEL libraries will also be addressed. 


Coverage will likely include:


  • On-DNA hit validation
  • Applications especially suited for DEL: Targeted Protein Degradation? 
  • Using DEL for covalent ligand discovery
  • Expanding DEL chemical space by machine learning and other methods 
  • Improving 3D and/or drug-like character of DEL libraries 
  • Other applications of DEL: for fragments, for macrocyclics
  • DEL for tough targets (flatter/single hit targets, GPCRs) 
  • Case studies of compounds from DEL screens progressing in development


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is October 8, 2021.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for this and the 4 concurrent day-and-a-half conferences during the first half of our 17th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda, whether you join in person or virtually.


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252

Email: ashah@healthtech.com


For partnering and sponsorship information, please contact:


Aimee Croke
Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5458
Email: acroke@cambridgeinnovationinstitute.com