Cambridge Healthtech Institute’s 2nd Annual
Protein-Protein Interactions
Small Molecule Discovery for Difficult Drug Targets
12 - 13 November 2025 ALL TIMES CET+1
Cambridge Healthtech Institute's Protein-Protein Interactions (PPIs) conference covers discovery, design, and optimization of small molecule and cell-permeable macrocyclic peptides that disrupt or stabilize intracellular protein-protein or protein-nucleic acid molecular complexes validated as disease targets. Misfolded or aberrant protein complexes are common drug targets in neurological, autoimmune and infectious diseases but are difficult-to-drug because the PPI sites are large and flat making it challenging for small molecules to form specific and multiple interactions with the target. However, PPIs have become more tractable due to recent advances in biophysical tools, covalent drug discovery strategies, fragment-based ligand approaches, structure-based drug design and targeted protein degradation (TPD) 'destroy what you can't inhibit' approaches. Join fellow medicinal, biophysical, and structural chemists to learn the latest, share insights, and discuss strategies.