Novel Strategies for Kinase Inhibitors  

 

ABOUT THIS CONFERENCE 

Kinases are now well established as a validated drug target class in cancer. However new light is being shed on their role in helping cancers resistant to conventional chemotherapy, representing topics that will be covered within this conference. Attendees will also learn about progress on promising preclinical and early clinical phase kinase inhibitor drug candidates in therapeutic areas beyond cancer, such as inflammation. Another focus of the Novel Strategies for Kinase Inhibitors conference will be on assay development and interpretation for new types of kinase inhibitors such as allosteric modulators and covalent inhibitors.

SUGGESTED EVENT PACKAGE:

September 23: New Class of Kinase Inhibitors: Covalent Modifiers Short Course
September 23: Advancing Tools and Technologies for Fragment-Based Design Short Course
September 24 - 25: Novel Strategies for Kinase Inhibitors Conference
September 25 - 26: Cardio-Metabolic Drug Targets Conference 


Scientific Advisory Board:

Jordan S. Fridman, Ph.D., Senior Director, Pharmacology, Incyte Corp.

William J. Pitts, Ph.D., Group Leader, Medicinal Chemistry, Bristol-Myers Squibb Co.

John Robinson, Ph.D., Senior Scientist, Medicinal Chemistry, Array BioPharma, Inc.

 

Beyond Cancer

Deregulated Cdk5-Targeted Inhibitor for Neuro-inflammation

Harish C. Pant, Ph.D., Chief, Laboratory of Cytoskeleton Protein Regulation, National Institute of Neurological Disease and Stroke, NIH


BTK Inhibitors in Inflammation and Autoimmunity

John Douhan III, Ph.D., Senior Principal Scientist, Immunoscience, Pfizer


Second Generation Janus Kinase Inhibitors

Jordan S. Fridman, Ph.D., Senior Director, Pharmacology, Incyte Corp.


ARRY-382, a Selective cFMS inhibitor for the Treatment of Osteolytic Bone Diseases

Dale Wright, Ph.D., Research Investigator, Senior Project Leader, Pharmacology, Array BioPharma Inc.

 

Covalent, Allosteric and New Types of Selective Inhibitors

JNK Inhibitor Discovery at Celgene - Tanzisertib and Beyond

Yoshitaka Satoh, Ph.D., Senior. Principal Scientist, Medicinal Chemistry, Celgene


Highly Selective Allosteric FMS Kinase inhibitors

Bryan Smith, Ph.D., Senior Scientist II, Biology, Deciphera Pharmaceuticals LLC


Exploiting a Serendipitous Binding Opportunity in the Development of Highly Selective Rho Kinase Inhibitors

Erick Young, Ph.D., Distinguished Research Fellow, Medicinal Chemistry and Research Administration, Boehringer Ingelheim Pharma

 

 

Kinase Inhibitors and Overcoming Cancer Drug Resistance

The Role of Growth Factors in Resistance to Anti-Cancer Kinase Inhibitors

Jeffrey Settleman, Ph.D., Senior Director, Discovery Oncology, Genentech


mTOR inhibitor Torin-1 for Targeting of Resistant Human Colon Cancer Stem Cells

Maria Giovanna Francipane, Ph.D., Post-Doctoral Research Scholar, Pathology, University of Pittsburgh


Development of c-MET kinase Inhibitors for Drug Resistant Cancers

Xiangdong Liu, Ph.D., Drug Discovery, Incyte Corporation